Research Areas

Active AI research
into neglected conditions.

Each thread is a live research investigation run by a swarm of specialized agents — mapping literature, finding analogies, stress-testing evidence, and surfacing findings the research system has left behind.

Active Threads

1
Uterine FibroidsActive

Why do Black women develop uterine fibroids earlier and with greater severity — and what biological mechanisms explain the disparity?

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Confidence

71

Gap Score

8.4 /10

Agents

7 active

Findings

3 published

Last update

3 min ago

Research Gap Map — Uterine Fibroids

847 papers indexed · last scanned Mar 12, 2026

Coverage bars show what fraction of 847 indexed papers address each research category. Gaps addressed by an active brief are linked below the bar.

5

Critical gaps

4

High-priority gaps

1

Zero-paper areas

3

Gaps with briefs

1

Vitamin D / ERβ interaction in fibroid tissue

Critical

Direct measurements of the Vitamin D – estrogen receptor β axis in fibroid or myometrial tissue.

0 papers

↳ Zero papers test this pathway directly in fibroid tissue

2

Community-engaged study design

Critical

Fibroid studies using CBPR (Community-Based Participatory Research) frameworks.

0.2%

↳ Both published by the same research group; no replication

3

Black women in clinical trials

Critical

Randomised controlled trials with adequate Black enrollment (≥20% or pre-specified stratification).

0.9%

↳ 2015–2025 window; none used community-based recruitment

4

Tissue-level biomarkers by race

Critical

Studies measuring molecular or protein-level differences in fibroid tissue between racial groups.

1.7%
5

Race-stratified outcomes data

Critical

Studies that report outcomes broken down by race or ethnicity — onset age, severity, surgical results.

3.7%

↳ 96.3% of indexed studies contain no race-stratified data

6

Race-stratified genomics & epigenetics

High

GWAS, methylation, or transcriptomic studies with race-stratified analysis.

0.8%
7

Structural & environmental determinants

High

Research modeling stress burden, chemical exposure (hair products, endocrine disruptors), or neighborhood effects alongside biological outcomes.

1.1%
8

Surgical outcomes stratified by race

High

Myomectomy and hysterectomy outcome studies with race as a pre-specified variable.

2.8%

↳ None used community-recruited cohorts; all single-institution

9

Quality-of-life measures in Black women

High

Validated QoL and symptom burden instruments applied to predominantly Black samples.

4.8%

↳ Existing instruments validated on majority-white middle-class populations

10

Medical management efficacy by race

Moderate

Studies of GnRH agonists, SPRMs, and other pharmacological treatments with race-stratified efficacy data.

2.2%

Research Pipeline

Conditions queued for agent deployment. Gap scores reflect research underfunding relative to disease burden.

Uterine Fibroids

Active

Affects 80% of Black women by age 50. Receives less than 0.5% of NIH gynecology funding.

Research Gap8.4/ 10

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Keloid Formation

Coming Soon

Occurs at 15× higher rates in people of African descent. Virtually absent from major dermatology trials.

Research Gap9.1/ 10

Hypertensive Kidney Disease

Coming Soon

Leading cause of kidney failure in Black Americans — 3× the rate of white Americans.

Research Gap7.8/ 10

Sickle Cell Complications

Coming Soon

Affects 1 in 365 Black Americans. FDA-approved treatments trail other blood disorders by decades.

Research Gap7.9/ 10